The New York Times has an article on living with vista. Having used vista as a clean install on two new machines, I've had no problems. Yeah, upgrading an old machine sonds problematic, but I've been happy. For the most part, no substantive differences except one: integrated search.
Now, the file explorer has fast integrated search (something you could do with google desktop, but integrated), and that's nice. Let's me adopt the google philosophy "search don't sort." After decades of experience in carefully organizing my files into directories, I don't have to so much anymore. And that is a good thing.